

Top compounds from this hackathon will be synthesized and tested in the lab, with qualifying hits eligible for up to $250K in TBXT Challenge prizes.Who should come: computational + medicinal chemists, molecular designers, engineers, computational biologists, AI/tool builders, and curious researchers interested in real discovery workflows.
Join us for an in-person small-molecule hackathon focused on TBXT/Brachyury, a clinically relevant transcription factor in chordoma and a notoriously difficult target.
This is a hit-generation challenge, not unconstrained de novo design. Teams will use muni, Rowan tools, onepot’s 3.4B compound library, or their own workflows to identify 4 ranked non-covalent TBXT ligands, with a short rationale for why each compound is structurally plausible, chemically sane, realistic to synthesize, and worth testing.
Schedule1:00pm — Doors open1:30pm — Announcements2:00pm — Team formation + hacking6:30pm — Dinner7:00pm — Final submissions + demos7:30pm — Judging + wrap-up
Bring a laptop. Come solo or with a team. Dinner and drinks provided.
In collaboration with Rowan and onepot. Hosted by Pillar VC with support from the Chordoma Foundation, AnyScale and OpenRouter.
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AI x Med Chem: Chordoma Small Molecule Hackathon is a free independent taking place on Saturday, May 9, 2026 at Pillar VC, 9th Floor, 500 Boylston St, Boston, MA 02116, USA, Boston, United States. Attendance is free — register to secure your spot. Currently 37 people have registered out of 37 spots. The event runs for approximately 7 hours.
Join this independent over 7 hours for an engaging session of learning, discussion, and networking with fellow attendees.
This independent in Boston is ideal for:
This evening independent is part of the growing events scene in Boston. Whether you're based in Boston or visiting for the independent, it's a great opportunity to connect with the local community. Browse more upcoming events in Boston on Rifio.
AI x Med Chem: Chordoma Small Molecule Hackathon covers topics including AI, Boston. Find similar events by browsing these topics on Rifio.