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AI x Med Chem: Chordoma Small Molecule Hackathon
May 9 – May 10, 2026
Pillar VC, 9th Floor, 500 Boylston St, Boston, MA 02116, USA, Boston, United States
37 attending
About this event
Top compounds from this hackathon will be synthesized and tested in the lab, with qualifying hits eligible for up to $250K in TBXT Challenge prizes.Who should come: computational + medicinal chemists, molecular designers, engineers, computational biologists, AI/tool builders, and curious researchers interested in real discovery workflows.
Join us for an in-person small-molecule hackathon focused on TBXT/Brachyury, a clinically relevant transcription factor in chordoma and a notoriously difficult target.
This is a hit-generation challenge, not unconstrained de novo design. Teams will use muni, Rowan tools, onepot’s 3.4B compound library, or their own workflows to identify 4 ranked non-covalent TBXT ligands, with a short rationale for why each compound is structurally plausible, chemically sane, realistic to synthesize, and worth testing.
Schedule1:00pm — Doors open1:30pm — Announcements2:00pm — Team formation + hacking6:30pm — Dinner7:00pm — Final submissions + demos7:30pm — Judging + wrap-up
Bring a laptop. Come solo or with a team. Dinner and drinks provided.
In collaboration with Rowan and onepot. Hosted by Pillar VC with support from the Chordoma Foundation, AnyScale and OpenRouter.
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Topics & Tags
AI
Boston
AI
Date & time
May 9 – May 10, 2026
America/New_York
Location
Pillar VC, 9th Floor, 500 Boylston St, Boston, MA 02116, USA, Boston, United States
America/New_York
Attendance
37 going · 37 spots
23 spots remaining
Type
independent
SourceLuma
UpdatedMay 3, 2026